Madhusudana S N, Anand N P
Department of Neurovirology, Ramiah Medical College, Bangalore, Karnataka, India.
Natl Med J India. 1997 May-Jun;10(3):115-6.
Post-exposure immunization of rabies with presently available cell culture vaccines in the regular five-dose intramuscular schedule is expensive for developing countries. In view of the latest World Health Organization recommendation on the use of the abbreviated intradermal regimen (now routinely followed in Thailand), we evaluated this regimen for the purified chick embryo cell vaccine.
Twenty-five subjects who had nursed or casually handled a rabies patient were administered purified chick embryo cell vaccine.
There was 100% seroconversion and all the subjects developed neutralizing antibody levels higher than the adequate level of 0.5 i.u./ml. Only minor side-effects were observed in some subjects.
The feasibility of using this regimen in routine practice needs to be evaluated further.
对于发展中国家而言，按照常规的五剂肌肉注射方案，使用目前现有的细胞培养疫苗进行狂犬病暴露后免疫接种成本高昂。鉴于世界卫生组织关于使用简化皮内接种方案（泰国目前常规采用）的最新建议，我们对纯化鸡胚细胞疫苗的该方案进行了评估。
对25名曾护理或偶尔接触狂犬病患者的受试者接种了纯化鸡胚细胞疫苗。
血清转化率达100%，所有受试者产生的中和抗体水平均高于0.5国际单位/毫升的充足水平。仅在部分受试者中观察到轻微的副作用。
该方案在常规实践中的可行性需要进一步评估。
