Sarrazin R, Brichon P Y, Chaffanjon P
Service de Clinique Chirurgicale, CHU de GRENOBLE, Hopital A. Michalton, Grenoble.
Ann Endocrinol (Paris). 1997;58(3):242-7.
Nine patients with mediastinal lymph node metastasis in differentiated thyroid carcinoma (7 papillary carcinomas, 1 Hürtle's cells carcinoma, 1 insular carcinoma) have been treated by systematic mediastinal dissection, 2 cases arose 6 and 10 years after the initial surgery, 2 cases after 18 and 20 months, but 5 revealed their metastases at the moment of the diagnosis or 3 months later. Investigations caused by a rise in thyroglobuline level (4 cases) necessarily involve a mediastinal CT scan, which always proved conclusive. All the patients underwent a median total sternotomy associated with a cervicotomy either for total thyroidectomy with conservative bilateral neck dissection, or for revision of the initial dissection. We describe the technique of mediastinal dissection allowing the resection of all the mediastinal lymph nodes. Mortality was zero and morbidity remained reasonable. 3 patients had recurrences: 2 died from multiple diffused metastases 18 months later, the third has pulmonary and mediastinal metastases well controlled by radio-iodine and external radiotherapy with a 5 years follow-up 6 are under total remission without sequel with a follow up ranging from 6 months to 8 years. Rather uncommon, total mediastinal dissection gives a long lasting remission with good living conditions to patients unresponsive to other therapies.
9例分化型甲状腺癌纵隔淋巴结转移患者(7例乳头状癌、1例嗜酸性细胞癌、1例岛状癌)接受了系统性纵隔清扫术,2例在初次手术后6年和10年出现转移,2例在18个月和20个月后出现,5例在诊断时或3个月后发现转移。因甲状腺球蛋白水平升高进行的检查(4例)必然包括纵隔CT扫描,结果均明确。所有患者均接受了正中全胸骨切开术联合颈部切开术,目的是进行全甲状腺切除术并保守性双侧颈部清扫,或对初次清扫进行修正。我们描述了能切除所有纵隔淋巴结的纵隔清扫技术。死亡率为零,发病率仍在可接受范围内。3例患者复发:2例在18个月后死于多发弥漫性转移,第3例有肺部和纵隔转移,经放射性碘和外照射放疗后得到良好控制,随访5年;6例完全缓解且无后遗症,随访时间为6个月至8年。全纵隔清扫术相当少见,但对于其他治疗无反应的患者,可带来长期缓解并改善生活质量。