肾移植中免疫抑制的发展与未来
The evolution and future of immunosuppression in renal transplantation.
作者信息
Goral S, Helderman J H
机构信息
Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232-2372, USA.
出版信息
Semin Nephrol. 1997 Jul;17(4):364-72.
PMID:9241720
Abstract
Since the early 1960s, a number of new immunosuppressive agents have been introduced to clinical transplantation. This review will be confined to mechanism of actions, and important gains and concerns of new microemulsion formulation of cyclosporine A (Neoral), mycophenolate mofetil (MMF), FK506, brequinar sodium, sirolimus (rapamycin), leflunomide, and 15-deoxyspergualin. We will also review some of the recent studies with monoclonal antibodies.
摘要
自20世纪60年代初以来，多种新型免疫抑制剂已被应用于临床移植。本综述将局限于环孢素A新微乳剂（新山地明）、霉酚酸酯、他克莫司、布喹那钠、西罗莫司（雷帕霉素）、来氟米特和15-去氧精胍菌素的作用机制、重要进展及相关问题。我们还将综述一些单克隆抗体的近期研究。
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