Syed M, Lesch M
Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202, USA.
Prog Cardiovasc Dis. 1997 Jul-Aug;40(1):77-84. doi: 10.1016/s0033-0620(97)80024-2.
Coronary artery aneurysm is defined as coronary dilatation which exceeds the diameter of normal adjacent segments or the diameter of the patient's largest coronary vessel by 1.5 times. This is an uncommon disease which has been diagnosed with increasing frequency since the advent of coronary angiography. The incidence varies from 1.5% to 5% with male dominance and a predilection for the right coronary artery. Atherosclerosis accounts for 50% of coronary aneurysms in adults. Reported complications include thrombosis and distal embolization, rupture and vasospasm. The natural history and prognosis remains obscure. Controversies persist regarding the use of surgical or medical management. The authors recommend surgery based on the severity of associated coronary stenosis rather than the mere presence of aneurysm. Medical therapy is indicated for the majority of patients and consists of antiplatelet and anticoagulant medication.
冠状动脉瘤被定义为冠状动脉扩张,其直径超过相邻正常节段的直径或患者最大冠状动脉血管直径的1.5倍。这是一种罕见疾病,自冠状动脉造影问世以来,其诊断频率不断增加。发病率在1.5%至5%之间,男性居多,且好发于右冠状动脉。动脉粥样硬化占成人冠状动脉瘤的50%。报道的并发症包括血栓形成和远端栓塞、破裂和血管痉挛。其自然病史和预后仍不明确。关于手术或药物治疗的使用仍存在争议。作者建议根据相关冠状动脉狭窄的严重程度而非仅仅依据动脉瘤的存在来决定是否手术。大多数患者适合药物治疗,包括使用抗血小板和抗凝药物。