p53和CD44作为结直肠癌发生中肿瘤进展的临床标志物。

p53 and CD44 as clinical markers of tumour progression in colorectal carcinogenesis.

作者信息

Mulder J W, Wielenga V J, Pals S T, Offerhaus G J

机构信息

Academic Medical Centre, University of Amsterdam, Department of Pathology, The Netherlands.

出版信息

Histochem J. 1997 Jun;29(6):439-52. doi: 10.1023/a:1026403404652.

DOI:10.1023/a:1026403404652

PMID:9248852

Abstract

Recent advances in molecular genetics have importantly improved our understanding of the development of colorectal cancer. The present review gives an overview of the clinical value of the tumour-suppressor gene, p53, and the CD44 cell adhesion molecule in colorectal cancer and the pitfalls encountered in the immunohistochemical detection of these proteins. Immunohistochemistry potentially forms a procedure applicable for routine diagnosis and prognostication. Therefore, p53 expression and the independent prognostic importance of CD44v6 expression is given particular emphasis, and other molecular events underlying colorectal carcinogenesis are only mentioned briefly.

摘要

分子遗传学的最新进展显著增进了我们对结直肠癌发生发展的理解。本综述概述了肿瘤抑制基因p53和CD44细胞黏附分子在结直肠癌中的临床价值，以及在这些蛋白免疫组化检测中遇到的问题。免疫组化有可能成为适用于常规诊断和预后评估的方法。因此，特别强调了p53表达及CD44v6表达的独立预后重要性，而结直肠癌发生的其他分子事件仅作简要提及。