胞质内嗜酸性包涵体（梅拉梅德-沃林斯卡小体）。与胸腔积液中的转移性移行细胞癌相关。
Intracytoplasmic eosinophilic inclusions (Melamed-Wolinska bodies). Association with metastatic transitional cell carcinoma in pleural fluid.
作者信息
Renshaw A A, Madge R, Granter S R
机构信息
Department of Pathology, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.
出版信息
Acta Cytol. 1997 Jul-Aug;41(4):995-8. doi: 10.1159/000332778.
OBJECTIVE
To determine if eosinophilic cytoplasmic inclusions (Melamed-Wolinska bodies) (ECIs) can help to distinguish metastatic transitional cell carcinoma (TCC) from pulmonary carcinoma (PC) in pleural effusions.
STUDY DESIGN
The presence of ECIs was evaluated in malignant pleural effusions from 8 cases (5 patients) of TCC and 38 cases of pulmonary carcinoma (PC). ECIs were categorized as absent, rare (< 2 per case), occasional (2 per case to < 1 per high-power field), frequent (1-2 per high-power field) or numerous (> 2 per high-power field).
RESULTS
In pleural fluids with TCC, ECIs were numerous in 1 case, frequent in 2 cases, occasional in 3 cases and absent in 2 cases. In contrast, in pleural fluids with PC, ECIs were occasional in 1 case, rare in 5 cases and absent in 32 cases.
CONCLUSION
While not present in every case, frequent ECIs in a malignant pleural effusion are suggestive of TCC rather than PC.
目的
确定嗜酸性细胞质包涵体（梅拉梅德 - 沃林斯卡小体）（ECIs）是否有助于鉴别胸腔积液中的转移性移行细胞癌（TCC）和肺癌（PC）。
研究设计
对8例（5名患者）TCC和38例肺癌（PC）的恶性胸腔积液中ECIs的存在情况进行评估。ECIs分为不存在、罕见（每例<2个）、偶见（每例2个至每高倍视野<1个）、常见（每高倍视野1 - 2个）或大量（每高倍视野>2个）。
结果
在TCC的胸腔积液中，1例ECIs大量存在，2例常见，3例偶见，2例不存在。相比之下，在PC的胸腔积液中，1例偶见ECIs，5例罕见，32例不存在。
结论
虽然并非在每个病例中都存在，但恶性胸腔积液中常见的ECIs提示为TCC而非PC。
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