Renshaw A A, Madge R, Granter S R
Department of Pathology, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.
Acta Cytol. 1997 Jul-Aug;41(4):995-8. doi: 10.1159/000332778.
To determine if eosinophilic cytoplasmic inclusions (Melamed-Wolinska bodies) (ECIs) can help to distinguish metastatic transitional cell carcinoma (TCC) from pulmonary carcinoma (PC) in pleural effusions.
The presence of ECIs was evaluated in malignant pleural effusions from 8 cases (5 patients) of TCC and 38 cases of pulmonary carcinoma (PC). ECIs were categorized as absent, rare (< 2 per case), occasional (2 per case to < 1 per high-power field), frequent (1-2 per high-power field) or numerous (> 2 per high-power field).
In pleural fluids with TCC, ECIs were numerous in 1 case, frequent in 2 cases, occasional in 3 cases and absent in 2 cases. In contrast, in pleural fluids with PC, ECIs were occasional in 1 case, rare in 5 cases and absent in 32 cases.
While not present in every case, frequent ECIs in a malignant pleural effusion are suggestive of TCC rather than PC.
确定嗜酸性细胞质包涵体（梅拉梅德 - 沃林斯卡小体）（ECIs）是否有助于鉴别胸腔积液中的转移性移行细胞癌（TCC）和肺癌（PC）。
对8例（5名患者）TCC和38例肺癌（PC）的恶性胸腔积液中ECIs的存在情况进行评估。ECIs分为不存在、罕见（每例<2个）、偶见（每例2个至每高倍视野<1个）、常见（每高倍视野1 - 2个）或大量（每高倍视野>2个）。
在TCC的胸腔积液中，1例ECIs大量存在，2例常见，3例偶见，2例不存在。相比之下，在PC的胸腔积液中，1例偶见ECIs，5例罕见，32例不存在。
虽然并非在每个病例中都存在，但恶性胸腔积液中常见的ECIs提示为TCC而非PC。
