阿扎哌隆及阿扎哌隆单一氧化氮的荧光特性。
Fluorescence characteristics of azaperone and of an azaperone mononitrogen oxide.
作者信息
Baeyens W, De Moerloose P, De Taeye L
出版信息
J Pharm Sci. 1977 Dec;66(12):1787-9. doi: 10.1002/jps.2600661239.
The structure elucidation of the compound isolated after peroxide treatment of azaperone is described. A mononitrogen oxide was formed at the piperazine N1 atom after reaction with excess hydrogen peroxide. The fluorescence characteristics of derivative were examined and compared with the native fluorescence capacities of the azaperone base; both were identical, depending on the solvent nature. The phenomenon is explained by the fact that the fluorescent properties of the azaperone molecule are principally produced by its ortho-nitrogen substituted pyridine nucleus.
描述了对氮杂哌酮用过氧化物处理后分离出的化合物的结构解析。与过量过氧化氢反应后，在哌嗪N1原子处形成了一种单氮氧化物。研究了衍生物的荧光特性，并与氮杂哌酮碱的天然荧光能力进行了比较；两者相同，这取决于溶剂性质。该现象可由以下事实解释：氮杂哌酮分子的荧光性质主要由其邻位氮取代的吡啶核产生。
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