4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide.

作者信息

Mrozik H, Bochis R J, Eskola P, Matzuk A, Waksmunski S, Olen L E, Schwartzkopf G, Grodski A, Linn B O, Lusi A, Wu M T, Shunk C H, Peterson L H, Milkowski J D, Hoff D R, Kulsa P, Ostlind D A, Campbell W C, Riek R F, Harmon R E

出版信息

J Med Chem. 1977 Sep;20(9):1225-7. doi: 10.1021/jm00219a025.

The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.