Lerner S F
Hospitales Oftalmologicos Santa Lucia y Pedro Lagleyze, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Ophthalmology. 1997 Aug;104(8):1237-41. doi: 10.1016/s0161-6420(97)30152-3.
Wound healing at the level of Tenon's capsule is a common cause of trabeculectomy failure. The purpose of this study is to present a new technique for glaucoma filtering surgery in which an injury to Tenon's capsule is minimized.
A 2.5-mm conjunctival peritomy was performed without cutting Tenon's capsule. A partial-thickness incision was made at the limbus and a scleral pocket was dissected 2 to 3 mm posteriorly. The subconjunctival space was entered with a cystotome passed through the scleral pocket, and balanced salt solution (BSS, Alcon Laboratories, Ft. Worth, TX) was injected, forming a subconjunctival bleb. In patients considered high risk, 5-fluorouracil (5 mg) was mixed with the BSS injected. The anterior chamber was entered at the initial limbal incision. A 1.5- by 1-mm fragment of the floor of the pocket was excised, followed by a peripheral iridectomy. The scleral wound, as well as the conjunctiva, was closed with separate 10-0 nylon sutures. This procedure was performed in 30 glaucomatous eyes. Seven high-risk eyes received four to seven postoperative injections of 5 mg of 5-fluorouracil.
Preoperative intraocular pressure (IOP) was 34.5 +/- 8.1 mmHg. Postoperative IOP was 13.2 +/- 4.1 at 6 months (P < 0.01), and 90% of the eyes had IOP less than or equal to 18 mmHg without medication. Mean follow-up was 7.6 months (range, 6-14 months). Blebs were low-lying and diffuse. No serious complications were encountered.
This new technique is a safe procedure that effectively reduces IOP. It is done through a small incision without sophisticated instruments. More cases and a prospective trial are needed to ascertain its potential advantages over those of conventional trabeculectomy.
眼球筋膜囊水平的伤口愈合是小梁切除术失败的常见原因。本研究的目的是介绍一种新的青光眼滤过手术技术,该技术可使眼球筋膜囊的损伤最小化。
进行2.5毫米的结膜周切术,不切开眼球筋膜囊。在角膜缘做一个部分厚度的切口,并向后分离2至3毫米的巩膜隧道。用一个通过巩膜隧道的囊膜刀进入结膜下间隙,并注入平衡盐溶液(BSS,爱尔康实验室,沃思堡,德克萨斯州),形成一个结膜下泡。对于被认为是高风险的患者,将5-氟尿嘧啶(5毫克)与注入的BSS混合。在最初的角膜缘切口处进入前房。切除隧道底部1.5×1毫米的碎片,然后进行周边虹膜切除术。巩膜伤口以及结膜用单独的10-0尼龙缝线缝合。该手术在30只青光眼眼中进行。7只高风险眼在术后接受了4至7次5毫克5-氟尿嘧啶的注射。
术前眼压(IOP)为34.5±8.1毫米汞柱。术后6个月眼压为13.2±4.1(P<0.01),90%的眼睛在不用药的情况下眼压小于或等于18毫米汞柱。平均随访时间为7.6个月(范围6至14个月)。滤过泡低平且弥散。未遇到严重并发症。
这种新技术是一种安全的手术方法,能有效降低眼压。它通过小切口完成,无需复杂器械。需要更多病例和前瞻性试验来确定其相对于传统小梁切除术的潜在优势。