Hanazaki K, Sodeyama H, Wakabayashi M, Miyazawa M, Yokoyama S, Sode Y, Kawamura N, Miyazaki T, Ohtsuka M
Department of Surgery, Nagano Red Cross Hospital, Japan.
Hepatogastroenterology. 1997 Jul-Aug;44(16):1126-32.
BACKGROUND/AIMS: It is crucial to improve the postoperative prognosis of patients with gastric cancer in geographic regions where the incidence of gastric cancer is high. This study compared the efficacy of surgical treatment in patients with gastric cancer detected by a mass screening survey with that of patients diagnosed in accordance with standard medical practice.
The subjects included 189 patients with gastric cancer detected by a mass screening survey (screening group) who underwent surgical treatment from 1988 to 1995, and 517 patients who underwent a standard medical work-up (non-screening group).
The incidence of early gastric cancer, curative resectability rate, and 5-year survival rates between the screening and non-screening groups were 73.0% versus 48.4% (p < 0.01), 90.5% versus 66.7% (p < 0.01), and 86.2% versus 61.0% (p < 0.01), respectively.
Surgical treatment for patients with gastric cancer identified by mass screening is effective in saving lives and reduces the mortality from gastric cancer in the target population of mass screening. However, a further prospective randomized controlled study of this screening method will be necessary in the future.
背景/目的:在胃癌高发地区,改善胃癌患者的术后预后至关重要。本研究比较了通过大规模筛查发现的胃癌患者与按照标准医疗实践诊断的患者的手术治疗效果。
研究对象包括1988年至1995年期间接受手术治疗的189例通过大规模筛查发现的胃癌患者(筛查组),以及517例接受标准医学检查的患者(非筛查组)。
筛查组和非筛查组的早期胃癌发病率、根治性切除率和5年生存率分别为73.0%对48.4%(p<0.01)、90.5%对66.7%(p<0.01)和86.2%对61.0%(p<0.01)。
对通过大规模筛查发现的胃癌患者进行手术治疗可有效挽救生命,并降低大规模筛查目标人群的胃癌死亡率。然而,未来有必要对这种筛查方法进行进一步的前瞻性随机对照研究。