使用非甾体抗炎药的消化性溃疡患者的血清胃蛋白酶原I和胃泌素

Serum pepsinogen I and gastrin in peptic ulcer patients using nonsteroidal anti-inflammatory drugs.

作者信息

Kemppainen H, Räihä I, Sourander L

机构信息

Department of Geriatric Medicine, University of Turku, Finland.

出版信息

Hepatogastroenterology. 1997 Jul-Aug;44(16):1143-6.

PMID:9261614

Abstract

BACKGROUND/AIMS: The inhibition of prostaglandin synthesis induced by nonsteroidal anti-inflammatory drugs (NSAIDs) have very complex effects on the gastric mucosa. They, for instance, inhibit mucosal cell proliferation in gastric ulcer patients. The aim of this study was to investigate whether these effects manifest as changes in pepsinogen I and gastrin concentrations.

METHODOLOGY

Fasting serum pepsinogen I and gastrin samples were collected from 53 consecutive Helicobacter pylori (HP) positive peptic ulcer patients. Ulcer was diagnosed by endoscopy. The presence of HP was determined from the histological specimen taken from the antral mucosa. Histological changes in the gastric mucosa were evaluated according to the Sydney system. A structured personal interview was carried out with all patients at endoscopy, including detailed questions on the daily use of NSAIDs. Patients were divided into two groups according to their use of NSAIDs.

RESULTS

The age-adjusted mean pepsinogen I concentration was significantly lower in patients who used NSAIDs compared to those who did not (91 vs 127 ng/l, p = 0.0035). There was no difference in the mean gastrin concentration between these two groups (91 vs 86 micrograms/l, p = 0.74).

CONCLUSIONS

Serum pepsinogen I concentration was lower in HP positive peptic ulcer patients who used NSAIDs compared to those who did not.

摘要

背景/目的：非甾体抗炎药（NSAIDs）诱导的前列腺素合成抑制对胃黏膜有非常复杂的影响。例如，它们会抑制胃溃疡患者的黏膜细胞增殖。本研究的目的是调查这些影响是否表现为胃蛋白酶原I和胃泌素浓度的变化。

方法

从53例连续的幽门螺杆菌（HP）阳性消化性溃疡患者中采集空腹血清胃蛋白酶原I和胃泌素样本。通过内镜检查诊断溃疡。从胃窦黏膜获取的组织学标本中确定HP的存在。根据悉尼系统评估胃黏膜的组织学变化。在内镜检查时对所有患者进行结构化个人访谈，包括关于NSAIDs日常使用的详细问题。根据患者对NSAIDs的使用情况将其分为两组。