两种钾通道阻滞剂（肥大细胞脱颗粒肽和树眼镜蛇毒素I）诱导的行为和神经退行性变

Behaviors and neurodegeneration induced by two blockers of K+ channels, the mast cell degranulating peptide and Dendrotoxin I.

作者信息

Mourre C, Lazdunski M, Jarrard L E

机构信息

Laboratoire de Neurobiologie des Comportements, UMR 6562 CNRS, IBHOP, Marseille, France.

出版信息

Brain Res. 1997 Jul 11;762(1-2):223-7. doi: 10.1016/s0006-8993(97)00481-2.

DOI:10.1016/s0006-8993(97)00481-2

PMID:9262178

Abstract

Both the Mast Cell Degranulating (MCD) peptide and Dendrotoxin I (DTX(I)), two blockers of fast activation and slowly inactivating K+ channels, induced epileptiform seizures and brain damage after intracerebroventricular injection (200 pmol) in Sprague-Dawley rats. A considerable variation in the response of the rats was observed for each toxin. The neurodegeneration included the hippocampal formation, subiculum, septum, amygdala, and the cerebellum for both toxins, and the neocortex and anterior thalamic nuclei exclusively for DTX(I) treatment.

摘要

肥大细胞脱颗粒（MCD）肽和树眼镜蛇毒素I（DTX(I)）这两种快速激活和缓慢失活钾通道阻滞剂，在向Sprague-Dawley大鼠脑室内注射（200皮摩尔）后，均可诱发癫痫样发作和脑损伤。观察到每种毒素处理的大鼠反应存在相当大的差异。两种毒素处理后，神经退行性变均包括海马结构、下托、隔区、杏仁核和小脑，而DTX(I)处理后仅新皮层和前丘脑核出现神经退行性变。