通过细胞周期蛋白D1表达分析结直肠癌的恶性程度

[Malignancy of colorectal cancer analyzed by expression of cyclin D1].

作者信息

Maeda K, Kang S M, Ogawa M, Chung Y S, Onoda N, Nakata B, Nishiguchi Y, Ikehara T, Okuno M, Sowa M

机构信息

First Dept. of Surgery, Osaka City University Medical School.

出版信息

Gan To Kagaku Ryoho. 1997 Jul;24 Suppl 2:259-62.

PMID:9263512

Abstract

We evaluated the clinical significance of cyclin D1 expression in colorectal adenocarcinoma. One hundred twenty-three specimens resected from patients with colorectal cancers were investigated by staining with a monoclonal antibody against cyclin D1. The possible correlations among cyclin D1 expression, clinicopathologic factors and prognosis were studied. There was no significant association between cyclin D1 expression and various clinicopathological factors. However, disease-free survival was significantly worse in the patients with cyclin D1 strongly positive tumors than in those with cyclin D1 negative tumors. Cyclin D1 overexpression may be useful as a predictor of disease recurrence in patients with colorectal adenocarcinoma.

摘要

我们评估了细胞周期蛋白D1在结直肠癌中的表达的临床意义。采用抗细胞周期蛋白D1单克隆抗体染色，对123例结直肠癌患者切除的标本进行了研究。研究了细胞周期蛋白D1表达、临床病理因素与预后之间的可能相关性。细胞周期蛋白D1表达与各种临床病理因素之间无显著相关性。然而，细胞周期蛋白D1强阳性肿瘤患者的无病生存期明显短于细胞周期蛋白D1阴性肿瘤患者。细胞周期蛋白D1过表达可能作为结直肠癌患者疾病复发的一个预测指标。