Seiden H S, Camuñas J L, Fishburger S B, Golinko R J, Steinberg L G, Shagong U, Rossi A F
Department of Pediatrics, Mount Sinai Medical Center, New York, New York 10029, USA.
Pacing Clin Electrophysiol. 1997 Aug;20(8 Pt 1):1967-74. doi: 10.1111/j.1540-8159.1997.tb03603.x.
The development of transvenous ventricular pacing leads with proximal electrodes capable of atrial sensing and the recent availability of smaller generators has created the opportunity to treat children with complete AV block and normal sinus node function with a transvenous single lead VDD pacing system. Studies in adults have demonstrated this system to be efficacious with low complication rates. Transvenous single lead VDD pacemakers were implanted in ten children, aged 5-15 years, between December 1993 and April 1996, in our institution. The indications were complete AV block with severe bradycardia in 5 patients, second-degree or complete AV block following congenital heart surgery in 3, complete AV block with long QT syndrome in 1, and second-degree AV block and syncope in 1. There were no complications related to the procedure in any case. P and R wave amplitudes were measured and thresholds were determined intraoperatively on all patients. Amplitudes and thresholds were remeasured on seven patients with a mean follow-up of 17 months; Holter monitors were performed on seven patients with mean follow-up of 16 months. P and R wave amplitudes were generally diminished at follow-up compared to initial values but remained within an acceptable range for all patients. Four patients required reprogramming after pacemaker insertion, 1 received an atrial lead for dual chamber pacing, 1 required reposition for lead dislodgment, and 1 patient required a new lead for an inadequate ventricular pacing threshold. No patient had evidence of failure to sense or capture as evaluated by Holter monitoring at last follow-up. Single lead VDD pacing systems can be successfully used in properly selected children with high degree or complete AV block with normal sinus node function.
能够进行心房感知的带有近端电极的经静脉心室起搏导线的发展以及近期更小起搏器的出现,为使用经静脉单导联VDD起搏系统治疗具有完全性房室传导阻滞且窦房结功能正常的儿童创造了机会。针对成人的研究已证明该系统有效且并发症发生率低。1993年12月至1996年4月期间,我们机构为10名年龄在5至15岁的儿童植入了经静脉单导联VDD起搏器。适应症包括:5例伴有严重心动过缓的完全性房室传导阻滞;3例先天性心脏手术后的二度或完全性房室传导阻滞;1例伴有长QT综合征的完全性房室传导阻滞;以及1例二度房室传导阻滞并伴有晕厥。所有病例均未出现与手术相关的并发症。术中对所有患者测量了P波和R波振幅并确定了阈值。对7例患者进行了重新测量,平均随访时间为17个月;对7例患者进行了动态心电图监测,平均随访时间为16个月。与初始值相比,随访时P波和R波振幅通常有所降低,但所有患者的数值仍在可接受范围内。4例患者在起搏器植入后需要重新编程,1例接受了心房导线用于双腔起搏,1例因导线脱位需要重新定位,1例患者因心室起搏阈值不足需要更换新导线。在最后一次随访时通过动态心电图监测评估,没有患者出现感知或夺获失败的证据。单导联VDD起搏系统可成功用于经过适当选择的、具有高度或完全性房室传导阻滞且窦房结功能正常的儿童。