胃活检标本中的局灶性炎症浸润提示克罗恩病。德国克罗恩病研究小组。

Focal inflammatory infiltrations in gastric biopsy specimens are suggestive of Crohn's disease. Crohn's Disease Study Group, Germany.

作者信息

Meining A, Bayerdörffer E, Bastlein E, Raudis N, Thiede C, Cyrus B, Krämer W, Klann H, Labenz J, Stolte M

机构信息

Dept. of Internal Medicine II, Klinikum Grosshadern, University of Munich, Germany.

出版信息

Scand J Gastroenterol. 1997 Aug;32(8):813-8. doi: 10.3109/00365529708996539.

DOI:10.3109/00365529708996539

PMID:9282974

Abstract

BACKGROUND

Crohn's disease is a systemic inflammatory disease that may involve all regions of the gut.

METHODS

Thirty-six patients with Crohn's disease and 36 age- and sex-matched control patients were prospectively evaluated by upper endoscopy. Biopsy specimens were taken from the oesophagus, duodenum, and 10 locations in the antrum and corpus.

RESULTS

Granulomas were found in four patients (11.13%) with Crohn's disease but in none of the control patients (P > 0.5). In 23 of 36 patients (63.9%) with Crohn's disease focal inflammatory infiltrations were found, as compared with 7 of 36 (19.4%) of the controls (P < 0.001). For focal inflammatory infiltrations, an odds ratio of 7.33 (2.55-21.38) was calculated, which increased to 20.04 (4.07-98.45) when only specimens from the angulus were considered. Helicobacter pylori infection was present in 13 of 36 controls (36.1%) and in 3 of 36 patients (8.3%) with Crohn's disease (P = 0.009).

CONCLUSION

These data suggest that Crohn's disease is typically associated with focal inflammatory infiltrations of the gastric mucosa.

摘要

背景

克罗恩病是一种全身性炎症性疾病，可累及肠道的所有区域。

方法

对36例克罗恩病患者和36例年龄及性别匹配的对照患者进行前瞻性上消化道内镜评估。从食管、十二指肠以及胃窦和胃体的10个部位获取活检标本。

结果

在4例（11.13%）克罗恩病患者中发现肉芽肿，而对照患者中均未发现（P>0.5）。36例克罗恩病患者中有23例（63.9%）发现局灶性炎症浸润，而对照组36例中有7例（19.4%）发现（P<0.001）。对于局灶性炎症浸润，计算出优势比为7.33（2.55 - 21.38），仅考虑角切迹部位的标本时，优势比增至20.04（4.07 - 98.45）。36例对照中有13例（36.1%）存在幽门螺杆菌感染，36例克罗恩病患者中有3例（8.3%）存在幽门螺杆菌感染（P = 0.009）。