Suzuki H
Saitama Medical School, Department of Nephrology.
Nihon Rinsho. 1997 Aug;55(8):2123-9.
Hypertension remains a leading cause of perinatal morbidity and mortality. Classification of the hypertensive disorders of pregnancy is 1) preeclampsia-eclampsia, 2) chronic hypertension, 3) chronic hypertension with superimposed preeclampsia-eclampsia. Preeclampsia is characterized by the triad of hypertension, proteinuria, and edema but these findings are not specific. Although the etiology and pathogenesis of preeclampsia remain unknown, several factors such as abnormalities in prostaglandin systems, in coagulation process, derangements of the endothelium and so on. Management of preeclampsia is bed rest, aspirin administration, antihypertensive agents (beta-blockers, hydralazine, alpha-methyldopa) would be used for reduction of blood pressure.
高血压仍然是围产期发病和死亡的主要原因。妊娠期高血压疾病的分类为：1）子痫前期-子痫，2）慢性高血压，3）慢性高血压并发子痫前期-子痫。子痫前期的特征是高血压、蛋白尿和水肿三联征，但这些表现并不具有特异性。尽管子痫前期的病因和发病机制尚不清楚，但有几个因素，如前列腺素系统异常、凝血过程异常、内皮功能紊乱等。子痫前期的治疗是卧床休息，使用阿司匹林，使用降压药物（β受体阻滞剂、肼屈嗪、甲基多巴）来降低血压。
