Simonon A, Mulder-Kampinga G A, van de Perre P, Karita E, Msellati P, Kuiken C, Goudsmit J
AIDS Reference Laboratory, National AIDS Control Program, Kigali, Rwanda.
J Gen Virol. 1997 Sep;78 ( Pt 9):2225-33. doi: 10.1099/0022-1317-78-9-2225.
The evolution of genomic RNA of human immunodeficiency virus type 1 (HIV-1), subtype A, was studied in three Rwandan mother-child pairs over a period of 12-30 months. In two pairs a homogeneous subtype A V3 sequence population was observed at seroconversion and the virus populations in the children resembled those in the mothers. One of these mother-child pairs was infected with an A/C recombinant virus (Ap17/Cp24). In the third pair, a heterogeneous V3 sequence population was observed in the maternal seroconversion sample but the V3 sequence population in the child's sample was homogeneous. In each individual the intra- and intersample variation (between the seroconversion and follow-up samples) increased over time in both the V3 region and p17gag. Independent evolution for 1-2 years did not abolish the epidemiological relationship between virus populations in mother and child.
在12至30个月的时间里，对卢旺达的三对母婴进行了研究，以观察1型人类免疫缺陷病毒（HIV-1）A亚型基因组RNA的演变情况。在两对母婴中，血清转化时观察到均一的A亚型V3序列群体，并且儿童体内的病毒群体与母亲体内的相似。其中一对母婴感染的是A/C重组病毒（Ap17/Cp24）。在第三对母婴中，母亲血清转化样本中观察到的是异质的V3序列群体，但儿童样本中的V3序列群体是均一的。在每个个体中，V3区域和p17gag的样本内和样本间变异（血清转化样本与随访样本之间）均随时间增加。病毒群体在母婴之间独立演变1至2年并未消除它们之间的流行病学关系。
