[一种以百日咳博德特氏菌抗原多价复合物为基础的无细胞百日咳疫苗]

[A polyvalent complex of Bordetella pertussis antigens as the basis for an acellular pertussis vaccine].

作者信息

Zakharova N S, Shmeleva E I, Remova T N, Bazhanova I G, Ozeretskovskaia M N, Mertsalova N U, Britsina M V, Ermolova E V, Zaĭtsev E M

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1997 May-Jun(3):70-2.

PMID:9304336

Abstract

The immunogenic and protective properties of acellular pertussis vaccines, prepared on the basis of B. pertussis multicomponent protective complex and the preparation containing only pertussis toxin, were studied. The study revealed that multicomponent preparations containing pertussis toxin (PT), filamentous hemagglutinin, agglutinogens, pertactin and adenylate cyclase possessed more pronounced immunobiological and protective properties in comparison with the monovalent preparation of PT, which was indicative of the expediency of developing acellular pertussis vaccines on the basis of the polyvalent protective complex as minor protective antigens seemed to enhance the protective action of pertussis toxoid, the main protective antigen.

摘要

研究了基于百日咳杆菌多组分保护性复合物制备的无细胞百日咳疫苗以及仅含百日咳毒素的制剂的免疫原性和保护特性。研究表明，与百日咳毒素单价制剂相比，含有百日咳毒素（PT）、丝状血凝素、凝集原、百日咳黏附素和腺苷酸环化酶的多组分制剂具有更明显的免疫生物学和保护特性，这表明基于多价保护性复合物开发无细胞百日咳疫苗是可行的，因为次要保护性抗原似乎增强了主要保护性抗原百日咳类毒素的保护作用。