拉莫三嗪可降低术后总镇痛需求：一项随机双盲、安慰剂对照的试点研究。
Lamotrigine reduces total postoperative analgesic requirement: a randomized double-blind, placebo-controlled pilot study.
作者信息
Bonicalzi V, Canavero S, Cerutti F, Piazza M, Clemente M, Chió A
机构信息
Department of Neurosciences, Institute of Anesthesia, University of Turin, Torino, Italy.
出版信息
Surgery. 1997 Sep;122(3):567-70. doi: 10.1016/s0039-6060(97)90129-x.
BACKGROUND
Postoperative pain is undertreated. Lamotrigine, a new antiepileptic drug, has analgesic properties in its antisodium and antiglutamatergic effects. It may prevent postoperative pain. This pilot study assessed lamotrigine effects on postoperative pain.
METHODS
This was a double-blind, randomized, placebo-controlled pilot study of 30 patients submitted to transurethral prostatectomy under spinal anesthesia and receiving 200 mg of lamotrigine 1 hour before spinal anesthesia.
RESULTS
We observed a statistically significant reduction in total analgesic assumption (p < 0.01) and in visual analog scale scores at 2 (p = 0.04), 4 (p < 0.01), and 6 (p = 0.04) hours after operation.
CONCLUSIONS
Lamotrigine may be an effective means of reducing postoperative pain.
背景
术后疼痛未得到充分治疗。拉莫三嗪是一种新型抗癫痫药物，具有抗钠和抗谷氨酸能作用，具有镇痛特性。它可能预防术后疼痛。这项前瞻性研究评估了拉莫三嗪对术后疼痛的影响。
方法
这是一项双盲、随机、安慰剂对照的前瞻性研究，纳入30例接受脊髓麻醉下经尿道前列腺切除术的患者，在脊髓麻醉前1小时给予200mg拉莫三嗪。
结果
我们观察到术后总镇痛药用量（p<0.01）以及术后2小时（p=0.04）、4小时（p<0.01）和6小时（p=0.04）视觉模拟量表评分有统计学意义的降低。
结论
拉莫三嗪可能是减轻术后疼痛的有效手段。
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