Mafrici A, Cioffi P, Alberti A
UCIC I Divisione, Dipartimento Cardiologico A. De Gasperis, Azienda Ospedaliera Niguarda Ca'Granda, Milano.
G Ital Cardiol. 1997 Aug;27(8):821-6.
Spontaneous coronary artery dissection is a rare cause of acute myocardial ischemia or death that is generally not detected until an autopsy is performed. It occurs in relatively young people and particularly in females. To date, its prognosis and treatment are not well defined. We describe our experience with one patient with acute myocardial infarction due to spontaneous dissection of the right coronary artery, which was treated successfully through direct coronary angioplasty. A 48-year-old man, heavy smoker, was admitted to our CCU for an acute inferior myocardial infarction with right ventricle involvement, which was complicated by the onset of cardiogenic shock (severe arterial hypotension, cold, pale and clammy skin, decrease in mental alertness, marked bradycardia due to a complete atrioventricular block). Since systemic thrombolysis was contraindicated (syncope followed by cranial trauma at the onset of symptoms), the patient underwent urgent coronary angiography that showed a proximal right coronary subocclusion with a filling defect and oblique linear density indicating possible dissection. Primary angioplasty was successfully attempted and a good distal flow was achieved (TIMI 3), but coronary artery dissection became more evident, with a double lumen extending over the distal segment just to the crux. Coronary stenting was not performed because optimum anticoagulant therapy was contra-indicated due to cranial trauma. Standard medical therapy was started after the procedure and coronary angiography, which was repeated before the patient was released from hospital, showed complete healing of the right coronary artery without any signs of dissection. The patient remained asymptomatic at a six-month follow-up check, with a negative exercise test. In our opinion, coronary angioplasty is a suitable therapeutic option in the treatment of spontaneous coronary dissection. More extensive experience is needed in order to standardize the most suitable therapeutic procedure in this rare cause of myocardial ischemia.
自发性冠状动脉夹层是急性心肌缺血或死亡的罕见原因,通常在尸检时才被发现。它发生在相对年轻的人群中,尤其是女性。迄今为止,其预后和治疗方法尚不明确。我们描述了一名因右冠状动脉自发性夹层导致急性心肌梗死患者的治疗经验,该患者通过直接冠状动脉血管成形术成功治愈。一名48岁男性,重度吸烟者,因急性下壁心肌梗死合并右心室受累入住我们的冠心病重症监护病房,并发心源性休克(严重动脉低血压、皮肤冰冷、苍白且湿冷、精神警觉性下降、因完全性房室传导阻滞导致明显心动过缓)。由于全身溶栓治疗存在禁忌(症状发作时出现晕厥并伴有颅脑外伤),患者接受了紧急冠状动脉造影,结果显示右冠状动脉近端次全闭塞,伴有充盈缺损和斜行线性密度影,提示可能存在夹层。成功尝试了一次原发性血管成形术,获得了良好的远端血流(TIMI 3级),但冠状动脉夹层变得更加明显,双腔延伸至远端节段直至十字交叉处。由于颅脑外伤,最佳抗凝治疗存在禁忌,因此未进行冠状动脉支架置入术。术后开始了标准药物治疗,在患者出院前重复进行的冠状动脉造影显示右冠状动脉完全愈合,无任何夹层迹象。在6个月的随访检查中,患者无症状,运动试验结果为阴性。我们认为,冠状动脉血管成形术是治疗自发性冠状动脉夹层的合适治疗选择。为了规范这种罕见的心肌缺血病因的最合适治疗方法,还需要更多广泛的经验。