阿替洛尔和普罗帕酮对心肌梗死后3个月患者QT间期离散度的影响。

The influence of atenolol and propafenone on QT interval dispersion in patients 3 months after myocardial infarction.

作者信息

Puljevic D, Smalcelj A, Durakovic Z, Goldner V

机构信息

Clinic for Cardiovascular Diseases, Medical University Zagreb, Croatia.

出版信息

Int J Clin Pharmacol Ther. 1997 Sep;35(9):381-4.

PMID:9314091

Abstract

UNLABELLED

The aim of the study was to determine changes in QTc dispersion and QTc interval during the administration of atenolol and propafenone.

METHODS

Eighty-five patients, 3 months after myocardial infarction, were randomized in 2 groups. The first group (n = 46) received atenolol 50 mg daily during 7 days and the second group (n = 39) propafenone 300 mg per os twice a day. QT interval was measured in 12 ECG leads before and after the treatment after 100% strip enlargement on a photocopy machine. For correction we used Bazett's formula. QTc dispersion was defined as the difference between the longest and the shortest QTc interval in 12 ECG leads.

RESULTS

QTc dispersion increased significantly with the severity of arrhythmia (< 50 premature ventricular complexes vs. ventricular tachycardia, 82.3 (18.1) vs. 110.0 (9.0) ms (p < 0.001)). QTc dispersion significantly decreases with the administration of atenolol (72.7 (14.8) vs. 63.6 (15.3)) (p < 0.001) as well as with propafenone (75.0 (17.7) vs. 63.2 (16.4)) (p < 0.001). QTc interval also decreases with atenolol (451 (28) vs. 431 (32)) (p < 0.01) while it does not change with propafenone administration (441 (26) vs. 444 (26)).

CONCLUSION

QTc dispersion is associated with ventricular tachycardia. Both atenolol and propafenone significantly decrease QTc dispersion. Atenolol also decreases QTc interval, while with propafenone it does not change.

摘要

未标记

本研究的目的是确定在使用阿替洛尔和普罗帕酮期间QTc离散度和QTc间期的变化。

方法

85例心肌梗死后3个月的患者被随机分为2组。第一组（n = 46）在7天内每天服用50 mg阿替洛尔，第二组（n = 39）每天口服300 mg普罗帕酮，分两次服用。在治疗前后，通过在复印机上对心电图进行100%放大后，测量12导联心电图的QT间期。校正时我们使用Bazett公式。QTc离散度定义为12导联心电图中最长QTc间期与最短QTc间期之差。

结果

QTc离散度随心律失常严重程度显著增加（< 50次室性早搏与室性心动过速相比，82.3（18.1）与110.0（9.0）ms（p < 0.001））。服用阿替洛尔后QTc离散度显著降低（72.7（14.8）与63.6（15.3））（p < 0.001），服用普罗帕酮后也显著降低（75.0（17.7）与63.2（16.4））（p < 0.001）。QTc间期服用阿替洛尔后也降低（451（28）与431（32））（p < 0.01），而服用普罗帕酮后无变化（441（26）与444（26））。