不可切除直肠癌的术前放疗和化疗
Pre-operative radiotherapy and chemotherapy for non-resectable rectal cancer.
作者信息
Leong T, Guiney M, Ngan S, Mackay J
机构信息
Division of Radiation Oncology, Peter MacCallum Cancer Institute, Australia.
出版信息
Aust N Z J Surg. 1997 Sep;67(9):603-6. doi: 10.1111/j.1445-2197.1997.tb04606.x.
BACKGROUND
The treatment results of combined pre-operative radiotherapy and chemotherapy followed by surgery for patients with initially non-resectable primary rectal cancer were reviewed.
METHODS
Thirteen patients with locally advanced non-resectable rectal cancer were treated with pre-operative irradiation consisting of 50.4-54 Gy plus concomitant 5-fluorouracil (5-FU) delivered during the 1st and 5th weeks of radiotherapy.
RESULTS
Following pre-operative therapy, the resectability rate was 91%, with all but one patient undergoing complete resection. The pathologic complete response rate was 10%. The overall peri-operative and postoperative complication rate was 0.8 complications per patient. There was no postoperative mortality.
CONCLUSIONS
This early experience indicates that high resectability rates are achievable with pre-operative radiotherapy and chemotherapy for non-resectable rectal cancer while maintaining acceptable postoperative morbidity.
背景
回顾性分析了初始不可切除的原发性直肠癌患者术前联合放疗和化疗后再行手术的治疗结果。
方法
13例局部晚期不可切除直肠癌患者接受术前放疗，剂量为50.4-54 Gy，在放疗的第1周和第5周同时给予5-氟尿嘧啶（5-FU）。
结果
术前治疗后，切除率为91%，除1例患者外均行根治性切除。病理完全缓解率为10%。围手术期和术后总体并发症发生率为每位患者0.8例。无术后死亡病例。
结论
这一早期经验表明，术前放疗和化疗可使不可切除直肠癌获得较高的切除率，同时保持可接受的术后发病率。
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