简短笔记。用纯化的牛碱性蛋白和佐剂诱导绵羊实验性变应性脑脊髓炎。
Brief note. Induction of experimental allergic encephalomyelitis in sheep with purified bovine basic protein and adjuvant.
作者信息
Ainsworth S K, Brostoff S, Sharbaugh R J, Fitts C T
出版信息
Pathology. 1979 Jul;11(3):457-60. doi: 10.3109/00313027909059022.
PMID:93263
Abstract
A large animal model for the induction of experimental allergic encephalomyelitis to study the immunological disease parameters through closed-circuit extracorporeal thoracic duct filtration was successfully produced in two different strains of sheep. This study demonstrates the advantages of using a well-defined antigen to obtain both rapid onset of disease and a higher percentage of animals succumbing to the illness.
摘要
通过闭路体外胸导管过滤诱导实验性变应性脑脊髓炎以研究免疫性疾病参数的大型动物模型，已在两种不同品系的绵羊中成功构建。本研究证明了使用明确抗原的优势，即能使疾病快速发作，且有更高比例的动物死于该疾病。
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Brief note. Induction of experimental allergic encephalomyelitis in sheep with purified bovine basic protein and adjuvant.简短笔记。用纯化的牛碱性蛋白和佐剂诱导绵羊实验性变应性脑脊髓炎。
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