Hutchinson W M
J Neurol Neurosurg Psychiatry. 1976 Mar;39(3):283-9. doi: 10.1136/jnnp.39.3.283.
In a retrospective survey of acute optic neuritis 144 cases in adults were found and, of these, 127 were reviewed, five had died of causes related to multiple sclerosis, and 12 were lost to follow-up. There was a statistically significant seasonal variation in the incidence of optic neuritis. When the life-table method of analysis was used, the probability of developing multiple sclerosis rises to 78% 15 years after an episode of optic neuritis. At review, 49 (73%) of the 67 patients with multiple sclerosis were independent and leading active lives.
在一项针对成人急性视神经炎的回顾性调查中,发现了144例病例,其中127例接受了复查,5例死于与多发性硬化相关的病因,12例失访。视神经炎的发病率存在统计学上显著的季节性变化。当采用生命表分析法时,视神经炎发作15年后患多发性硬化的概率升至78%。复查时,67例多发性硬化患者中有49例(73%)独立生活且生活积极。