Sunderland S
J Neurol Neurosurg Psychiatry. 1976 May;39(5):471-80. doi: 10.1136/jnnp.39.5.471.
A study of the clinical features of causalgia and the central neuronal effects of injuries to peripheral nerves suggests that causalgia is the functional expression of the intensity of the retrograde neuronal reaction in which pools of dorsal horn neurones become converted into foci of abnormal activity. These foci initiate a chain reaction along transmission pathways as far centrally as the cortex, causalgia being the terminal effect of this disorderly activity on the sensorium. This is the basis of the 'turbulance hypothesis' introduced to account for the pain.
一项关于灼性神经痛临床特征及外周神经损伤对中枢神经元影响的研究表明,灼性神经痛是逆行性神经元反应强度的功能性表现,其中背角神经元池转变为异常活动灶。这些病灶沿传导通路引发连锁反应,直至中枢的皮质,灼性神经痛就是这种紊乱活动对感觉中枢的最终影响。这就是为解释疼痛而提出的“紊乱假说”的基础。