双侧夹闭颈动脉对小鼠癫痫易感性及AOAA中枢作用的影响。
Influence of bilateral clamping of carotid arteries on the seizures susceptibility and central action of AOAA in mice.
作者信息
Sieklucka-Dziuba M, Tokarski R, Józwiak L, Kleinrok Z
机构信息
Department of Pharmacology, Medical University School, Lublin, Poland.
出版信息
Acta Physiol Hung. 1996;84(4):453-5.
In the experiments carried out on Albino-Swiss mice it was found, that bilateral clamping of carotid arteries (BCCA) for 30 min produce the increase of GABA content in hippocampus, striatum and frontal cortex and decrease of the seizures susceptibility to bicuculline, investigated 7 days after surgery. Moreover, BCCA modulates the action of aminooxyacetic acid (AOAA): potentiates anticonvulsive effect of low doses of AOAA (33 mg/kg) and inhibits the convulsive action of high doses. Also the potentiation of the anticonvulsive effect of diazepam, phenobarbital and valproic acid (VPA) was observed in BCCA and AOAA (CD97, 150 mg/kg) treated animals. Observed effects suggests that enhanced GABA-ergic activity and decrease of excitatory amino acid (EAA) system could be involved in these processes.
在对白化瑞士小鼠进行的实验中发现，双侧颈总动脉夹闭（BCCA）30分钟会使海马体、纹状体和额叶皮质中的GABA含量增加，并降低术后7天对荷包牡丹碱癫痫发作的易感性。此外，BCCA调节氨基氧乙酸（AOAA）的作用：增强低剂量AOAA（33mg/kg）的抗惊厥作用，并抑制高剂量的惊厥作用。在接受BCCA和AOAA（CD97，150mg/kg）治疗的动物中还观察到地西泮、苯巴比妥和丙戊酸（VPA）抗惊厥作用的增强。观察到的这些效应表明，GABA能活性增强和兴奋性氨基酸（EAA）系统的减少可能参与了这些过程。
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