Shupak A, Tabari R, Swarts J D, Bluestone C D, Doyle W J
Department of Pediatric Otolaryngology, Children's Hospital of Pittsburgh, Pennsylvania, USA.
Laryngoscope. 1997 Oct;107(10):1409-13. doi: 10.1097/00005537-199710000-00021.
Middle ear negative pressure and effusions, decreased middle ear compliance, and abnormal tympanometry results have been described after diving on oxygen. Middle ear gas hyperoxia has been shown to down-regulate the eustachian tube ventilatory function (ETVF). The purpose of the present study was to investigate to what extent systemic hyperoxia in the face of air-equivalent middle ear gas composition might interfere with the ETVF. ETVF was investigated in four young adult female cynomolgus monkeys by the forced-response and inflation-deflation tests using air while the animals breathed either room air or 100% normobaric oxygen. Higher opening, closing, and steady-state pressures were observed under systemic hyperoxia. The percentage of the applied pressure equalized, and the maximal pressure change on a single swallow in the deflation test were both lower under hyperoxic conditions. The results show that systemic hyperoxia might impair ETVF. This observation adds to our understanding of the pathophysiology of middle ear dysfunction observed after diving on oxygen.
在使用氧气潜水后，已观察到中耳负压和积液、中耳顺应性降低以及鼓室导抗图结果异常。中耳气体高氧已被证明会下调咽鼓管通气功能（ETVF）。本研究的目的是调查在中耳气体成分与空气等效的情况下，全身性高氧会在多大程度上干扰ETVF。通过在动物呼吸室内空气或100%常压氧气时使用空气进行强制反应和充放气测试，对四只成年雌性食蟹猴的ETVF进行了研究。在全身性高氧条件下，观察到更高的开放压、关闭压和稳态压力。在高氧条件下，充放气测试中施加压力平衡的百分比以及单次吞咽时的最大压力变化均较低。结果表明，全身性高氧可能会损害ETVF。这一观察结果有助于我们理解在使用氧气潜水后观察到的中耳功能障碍的病理生理学。
