脂质体制霉菌素对中性粒细胞减少小鼠播散性烟曲霉感染的活性。
Activity of liposomal nystatin against disseminated Aspergillus fumigatus infection in neutropenic mice.
作者信息
Wallace T L, Paetznick V, Cossum P A, Lopez-Berestein G, Rex J H, Anaissie E
机构信息
Aronex Pharmaceuticals, Inc., The Woodlands, Texas 77381, USA.
出版信息
Antimicrob Agents Chemother. 1997 Oct;41(10):2238-43. doi: 10.1128/AAC.41.10.2238.
The purpose of this study was to examine the activity of liposomal nystatin against a disseminated Aspergillus fumigatus infection in neutropenic mice. Mice were made neutropenic with 5-fluorouracil and were administered the antifungal drug intravenously for 5 consecutive days beginning 24 h following infection. Liposomal nystatin, at doses as low as 2 mg/kg of body weight/day, protected neutropenic mice against Aspergillus-induced death in a statistically significant manner at the 50-day time point compared to either the no-treatment, the saline, or the empty-liposome group. This protection was approximately the same as that for free nystatin, a positive control. Histopathological results showed that liposomal nystatin cleared the lungs, spleen, pancreas, kidney, and liver of Aspergillus and that there was no organ damage at the day 5 time point, which was after only three doses of liposomal nystatin. Based on these results in mice, it is probable that liposomal nystatin will be effective against Aspergillus infection in humans.
本研究的目的是检测脂质体制霉菌素对中性粒细胞减少小鼠播散性烟曲霉感染的活性。用5-氟尿嘧啶使小鼠中性粒细胞减少，并在感染后24小时开始连续5天静脉给予抗真菌药物。与未治疗组、生理盐水组或空脂质体组相比，脂质体制霉菌素以低至2mg/kg体重/天的剂量，在50天时间点以统计学显著方式保护中性粒细胞减少小鼠免受曲霉诱导的死亡。这种保护作用与阳性对照游离制霉菌素大致相同。组织病理学结果显示，脂质体制霉菌素清除了肺、脾、胰腺、肾和肝脏中的曲霉，并且在仅给予三剂脂质体制霉菌素后的第5天时间点没有器官损伤。基于小鼠的这些结果，脂质体制霉菌素很可能对人类曲霉感染有效。
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