Kulińska-Niedziela I, Paluszak J
Katedra i Zakład Fizjologii Akademii Medycznej im. Karola Marcinkowskiego w Poznaniu.
Postepy Hig Med Dosw. 1997;51(3):329-42.
Neurotensin is a 13-amino acid hormonal peptide which was first isolated from bovine hypothalamus. It is present in the digestive tract as well as in the central nervous system. It has a variety of biological activities as a central neurotransmitter or neuromodulator, and a peripheral hormone. NT receptors have been characterized in a variety of tissues and cell lines of peripheral and central organs. The physiological functions of NT include stimulation of pancreatic and biliary secretion, stimulation of colonic motility, inhibition of small bowel and gastric motility, trophic effect on numerous tissues of the gastrointestinal tract. NT exerts hypothermic and analgesic effect when injected into the central nervous system. From a clinical standpoint, studies with NT have led to implications of its involvement in schizophrenia, Parkinson's disease and Alzheimer's disease.
神经降压素是一种由13个氨基酸组成的激素肽，最初从牛下丘脑分离出来。它存在于消化道以及中枢神经系统中。作为一种中枢神经递质或神经调节剂以及外周激素，它具有多种生物活性。神经降压素受体已在周围和中枢器官的多种组织和细胞系中得到表征。神经降压素的生理功能包括刺激胰腺和胆汁分泌、刺激结肠蠕动、抑制小肠和胃蠕动、对胃肠道许多组织的营养作用。当注入中枢神经系统时，神经降压素会产生降温及镇痛作用。从临床角度来看，对神经降压素的研究表明它与精神分裂症、帕金森病和阿尔茨海默病有关。
