卵磷脂化超氧化物歧化酶对博来霉素诱导的小鼠间质性肺炎模型的影响。

Effect of lecithinized-superoxide dismutase on the interstitial pneumonia model induced by bleomycin in mice.

作者信息

Yamazaki C, Hoshino J, Hori Y, Sekiguchi T, Miyauchi S, Mizuno S, Horie K

机构信息

Tokyo Research Institute, Seikagaku Corporation, Tokyo, Japan.

出版信息

Jpn J Pharmacol. 1997 Sep;75(1):97-100. doi: 10.1254/jjp.75.97.

DOI:10.1254/jjp.75.97

PMID:9334891

Abstract

Superoxide anion (O2-) acts as an exacerbation factor in interstitial pneumonia. Lecithinized-superoxide dismutase (PC-SOD), which is synthesized with a lecithin derivative bound covalently to recombinant human Cu,Zn-SOD, has a longer half-life in plasma and higher affinity to cell membranes than unmodified SOD. The effect of PC-SOD was evaluated using the bleomycin-induced interstitial pneumonia mouse model. Treatment with PC-SOD at 10 mg/kg significantly reduced the hydroxyproline content and fibrosis score. Namely, PC-SOD suppressed the progression of pulmonary fibrosis on the bleomycin-induced interstitial pneumonia mouse model. PC-SOD may be a potential drug for interstitial pneumonia therapy.

摘要

超氧阴离子（O2-）在间质性肺炎中作为一种加重因素。卵磷脂化超氧化物歧化酶（PC-SOD）是通过将卵磷脂衍生物与重组人铜锌超氧化物歧化酶共价结合而合成的，与未修饰的超氧化物歧化酶相比，它在血浆中的半衰期更长，对细胞膜的亲和力更高。使用博来霉素诱导的间质性肺炎小鼠模型评估了PC-SOD的作用。以10mg/kg的剂量用PC-SOD治疗可显著降低羟脯氨酸含量和纤维化评分。也就是说，PC-SOD在博来霉素诱导的间质性肺炎小鼠模型中抑制了肺纤维化的进展。PC-SOD可能是治疗间质性肺炎的一种潜在药物。