[诱导型一氧化氮合酶在大鼠应激性急性胃黏膜损伤中的作用]

[Role of inducible nitric oxide synthase in acute gastric mucosal damage in stress, in rats].

作者信息

Laudanno O M, Cesolari J A, San Miguel P, Bedini O A

机构信息

Cátedras de Gastroenterología y de Histología, Facultad de Ciencias Médicas de Rosario, Argentina.

出版信息

Acta Gastroenterol Latinoam. 1996;26(4):221-4.

PMID:9335925

Abstract

In groups of female Wistar rats, someted to stress by immobilization and immersion in 18 degrees C water during 6 hrs, the role of nitric oxide (NO) in its pathophysiologic was studied. Agonist and antagonist of the isoforms Constitutive NO Synthase (cNOS) and of the inducible NO Synthase (iNOS) were used. Was found that the overdose of L-arginine aggravated of stress acute gastric lesions. The agonist of iNOS the NMDA and the antagonists dexamethasone and aminoguanidine were used. The NMDA aggravated the stress acute gastric lesions; in contrast, dexamethasone and aminoguanidine given a evident protection of the gastric mucosa in stress. Was concluded that the production of NO given by iNOS, play a role important in the pathophysiologic in stress acute gastric lesions.

摘要

在一组雌性Wistar大鼠中，通过固定和浸入18摄氏度的水中6小时使其遭受应激，研究了一氧化氮（NO）在其病理生理学中的作用。使用了组成型一氧化氮合酶（cNOS）和诱导型一氧化氮合酶（iNOS）同工型的激动剂和拮抗剂。发现过量的L-精氨酸会加重应激性急性胃损伤。使用了iNOS激动剂NMDA以及拮抗剂地塞米松和氨基胍。NMDA加重了应激性急性胃损伤；相反，地塞米松和氨基胍对处于应激状态的胃黏膜有明显的保护作用。得出的结论是，iNOS产生的NO在应激性急性胃损伤的病理生理学中起重要作用。