纤维蛋白胶对放射性结肠吻合口的影响。
Effect of fibrin glue on irradiated colonic anastomoses.
作者信息
Karahasanoglu T, Alcicek S, Altunkaya E, Sahinler I, Goksel S, Sirin F, Ozbal A
机构信息
Department of Surgery, Istanbul University Cerrahpasa Medical School, Turkey.
出版信息
Dis Colon Rectum. 1997 Oct;40(10):1240-3. doi: 10.1007/BF02055171.
INTRODUCTION
The present study was planned to research the effects of fibrin glue on irradiated colonic anastomoses.
METHOD
The effect of fibrin glue on irradiated colonic anastomoses was investigated in four identical groups of rats. In Group I (control group) colonic anastomoses were performed without radiotherapy; in Group II, colonic anastomoses were performed five days after radiotherapy; in Group III, fibrin glue was applied to anastomotic line without radiotherapy; in Group IV, fibrin glue was applied to anastomotic line with radiotherapy. The healing of left colonic anastomoses was evaluated through the bursting pressure of the anastomotic segment and the hydroxyproline contents of the anastomosis.
RESULTS
Measurements done on the fourth postoperative day revealed that anastomotic healing was impaired in rats that underwent radiotherapy (P < 0.001); fibrin glue had no effect on anastomotic healing in groups with or without radiotherapy.
CONCLUSION
In the early phases of anastomotic healing, fibrin glue cannot help remove unwanted effects of preoperative radiotherapy.
引言
本研究旨在探讨纤维蛋白胶对受照射结肠吻合口的影响。
方法
在四组相同的大鼠中研究纤维蛋白胶对受照射结肠吻合口的影响。第一组（对照组）未进行放疗即行结肠吻合术；第二组在放疗五天后行结肠吻合术；第三组未进行放疗，在吻合口处应用纤维蛋白胶；第四组在放疗的同时在吻合口处应用纤维蛋白胶。通过吻合段的破裂压力和吻合口的羟脯氨酸含量评估左半结肠吻合口的愈合情况。
结果
术后第四天的测量结果显示，接受放疗的大鼠吻合口愈合受到损害（P < 0.001）；纤维蛋白胶对接受或未接受放疗的组的吻合口愈合均无影响。
结论
在吻合口愈合的早期阶段，纤维蛋白胶无法消除术前放疗的不良影响。
Zotero 插件