Sikora J, Słodkowska J, Radomyski A, Giedronowicz D, Kobos J, Kupis W, Rudzinski P
National Institute of Tuberculosis and Lung Diseases, Warsaw and Medical Academy, Lódź.
Rocz Akad Med Bialymst. 1997;42 Suppl 1:271-9.
Experimental studies revealed that growth and expansion of solid tumours depend on angiogenesis. Angiogenesis is very important factor for neoplastic metastasis. The presence of the metastasis is an ominous prognostic factor for many tumours, also for lung cancer. Studies of tumour microvessel density in resected non-small lung cancers have not given convincing data about value of angiogenesis. Only few reports regarded the association with angiogenesis in different histological types in lung carcinoma. Samples of 35 adenocarcinomas and 41 squamous cell resected, primary lung carcinomas were studied. Paraffin sections of tumours were stained immunohistochemically by antibody against endothelial marker CD34. Angiogenesis intensity was measured in the areas of the most active fields of tumour neovascularization. Microvessel density (MD) was higher in adenocarcinoma comparing to squamous cell cancer, but the difference was not statistically significant (p = 0,095). The groups of various stage of extension of disease in each histological type were compared-MD correlated with lymph node metastasis (p = 0,003) in the adenocarcinoma, whilst in squamous cell can cer differences between various groups of nodal involvement were not statistically significant (p = 0,53 and p = 0,22 respectively). Our results suggest that more intensive angiogenesis in adenocarcinoma could be more important factor for metastasis of adenocarcinoma than for squamous tumours. In the latter group angiogenesis may be more important for growth of squamous cell cancers, while the spread of squamous tumours may depend on other mechanisms.
实验研究表明，实体瘤的生长和扩展依赖于血管生成。血管生成是肿瘤转移的一个非常重要的因素。转移的存在对许多肿瘤来说都是一个不祥的预后因素，对肺癌也是如此。对切除的非小细胞肺癌中的肿瘤微血管密度进行研究，尚未得出关于血管生成价值的确凿数据。仅有少数报告涉及肺癌不同组织学类型与血管生成的关联。对35例腺癌和41例切除的原发性肺鳞癌样本进行了研究。肿瘤石蜡切片用抗内皮标志物CD34的抗体进行免疫组织化学染色。在肿瘤新生血管最活跃的区域测量血管生成强度。腺癌的微血管密度（MD）高于鳞癌，但差异无统计学意义（p = 0.095）。比较了每种组织学类型中疾病不同扩展阶段的组——腺癌中MD与淋巴结转移相关（p = 0.003），而在肺鳞癌中，不同淋巴结受累组之间的差异无统计学意义（分别为p = 0.53和p = 0.22）。我们的结果表明，腺癌中更强烈的血管生成可能对腺癌转移比对鳞癌更重要。在鳞癌组中，血管生成可能对鳞状细胞癌的生长更重要，而鳞状肿瘤的扩散可能取决于其他机制。
