Bruzzese E, Greco G, Maniscalco A, Del Litto M
Minerva Med. 1976 May 12;67(24):1584-9.
Urinary creatine and creatinine excretion in rats treated by HN-2 ("bb'-dichlorodiethyl-N-methylamine") has been studied as function of dose and time from administration. Experimental results obtained in treated animals show an increased urinary excretion for creatine and decreased urinary excretion for creatinine. The variations are correctly related with the dose. Observed modifications are compared with the informations about urinary creatine and creatinine excretion after ionizing radiations exposure. Within research bounds, experimental results let to regard studied compounds as a possible biological dose indicators in the HN-2 intoxication.
对用 HN - 2（“双（β，β - 二氯乙基）甲胺”）处理的大鼠的尿肌酸和肌酐排泄量随给药剂量和时间的变化进行了研究。在接受处理的动物身上获得的实验结果表明，尿肌酸排泄量增加，而尿肌酐排泄量减少。这些变化与剂量呈正相关。将观察到的变化与电离辐射暴露后尿肌酸和肌酐排泄的相关信息进行了比较。在研究范围内，实验结果表明所研究的化合物有可能作为 HN - 2 中毒的生物剂量指标。
