Granata A R, Rochira V, Lerchl A, Marrama P, Carani C
Department of Internal Medicine, University of Modena, Italy.
J Androl. 1997 Sep-Oct;18(5):522-7.
In order to identify a possible threshold for a serum testosterone level below which sleep-related erections are impaired and to compare this threshold with the normal laboratory range of testosterone serum levels, we studied 201 men, including hypogonadal and eugonadal subjects. The protocol included nocturnal penile tumescence and rigidity monitoring and the assay of basal testosterone, prolactin, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) serum levels. The subjects were assigned to eight groups according to their testosterone serum levels. Group 1 had testosterone between 0 ng/dl and 99 ng/dl; the following seven groups had testosterone levels increased by 100 ng/dl per group. The groups of subjects with higher testosterone serum levels showed almost constantly higher values for the erectile parameters we studied than the subjects with serum testosterone < or = 99 ng/dl. On the contrary, subjects with higher testosterone serum levels showed higher values for only some erectile parameters compared to the subjects with serum testosterone between 100 and 199 ng/dl, without any significant difference among the groups with testosterone serum levels in the normal range. Our data suggest that the serum testosterone threshold for sleep-related erections is lower than the low end of the normal laboratory male range and is about 200 ng/dl. Further efforts are needed to find the precise serum testosterone ranges related to normal sleep-related erections and to normal sexual behavior, the testosterone ranges of which will probably not coincide.
为了确定血清睾酮水平低于何种阈值会损害与睡眠相关的勃起功能，并将该阈值与睾酮血清水平的正常实验室范围进行比较，我们研究了201名男性，包括性腺功能减退和性腺功能正常的受试者。研究方案包括夜间阴茎肿胀和硬度监测以及基础睾酮、催乳素、促黄体生成素（LH）和促卵泡生成素（FSH）血清水平的检测。根据受试者的睾酮血清水平将其分为八组。第1组的睾酮水平在0 ng/dl至99 ng/dl之间；接下来的七组每组睾酮水平递增100 ng/dl。与血清睾酮≤99 ng/dl的受试者相比，血清睾酮水平较高的受试者组在我们研究的勃起参数方面几乎始终显示出更高的值。相反，与血清睾酮水平在100至199 ng/dl之间的受试者相比，血清睾酮水平较高的受试者仅在某些勃起参数上显示出更高的值，而睾酮血清水平在正常范围内的各组之间没有任何显著差异。我们的数据表明，与睡眠相关勃起的血清睾酮阈值低于正常实验室男性范围的下限，约为200 ng/dl。需要进一步努力来确定与正常睡眠相关勃起和正常性行为相关的精确血清睾酮范围，这两个睾酮范围可能并不一致。
