Yang J H, Wu M Y, Chao K H, Chen S U, Ho H N, Yang Y S
Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, R.O.C.
J Reprod Med. 1997 Oct;42(10):663-8.
To determine whether subjects with an elevated ratio of follicle-stimulating hormone (FSH) to luteinizing hormone (LH) but normal basal FSH levels should be regarded as poor responders to controlled ovarian hyperstimulation.
One hundred twenty-five women undergoing in vitro fertilization (IVF) for the first time were recruited in this retrospective cohort study. Women over 40 years old or having serum basal FSH > 10 mIU/mL were excluded.
Various cutoff values for the FSH/LH ratio were chosen, and the ratio demonstrated that pregnancy rates were apparently higher in patients with the long protocol than with the short one if they had an FSH/LH ratio < 3.0 (48.5% vs. 25.8%, P = .034), < 2.5 (53.3% vs. 28.6%, P = .030) or < 2.0 (57.8% vs. 21.7%, P = .005). Pregnancy rates were similar with the long and short protocols in patients with FSH/LH > or = 3.0 (57.1% vs. 70%, P = .521), FSH/LH > or = 2.5 (40% vs. 53.8%, P = .435) or FSH/LH > or = 2.0 (40% vs. 55.6%, P = .281).
This study failed to demonstrate that FSH/LH was a useful parameter for predicting reproductive outcome in IVF programs and for patient selection for the long or short gonadotropin-releasing hormone agonist protocol.
确定促卵泡激素（FSH）与促黄体生成素（LH）比值升高但基础FSH水平正常的受试者是否应被视为控制性卵巢刺激反应不良者。
在这项回顾性队列研究中招募了125名首次接受体外受精（IVF）的女性。排除40岁以上或血清基础FSH>10 mIU/mL的女性。
选择了FSH/LH比值的各种临界值，该比值表明，采用长方案且FSH/LH比值<3.0（48.5%对25.8%，P = 0.034）、<2.5（53.3%对28.6%，P = 0.030）或<2.0（57.8%对21.7%，P = 0.005）的患者，其妊娠率明显高于采用短方案的患者。FSH/LH≥3.0（57.1%对70%，P = 0.521）、FSH/LH≥2.5（40%对53.8%，P = 0.435）或FSH/LH≥2.0（40%对55.6%，P = 0.281）的患者，长方案和短方案的妊娠率相似。
本研究未能证明FSH/LH是预测IVF程序中生殖结局以及选择长效或短效促性腺激素释放激素激动剂方案患者的有用参数。
