Libertun C, Mccann S M
Proc Soc Exp Biol Med. 1976 Jun;152(2):143-6. doi: 10.3181/00379727-152-39347.
Bilateral implants of atropine sulphate were placed in various loci in the brain or into the anterior pituitary in male rats and the effects of the implants on the postcastration rise in plasma FSH and LH was determined. The increase in both gonadotropins at 16 hr after castration still occurred in animals with implants in the cerebral cortex. The postcastration rise of both FSH and LH was blocked by atropine implants in the anterior, middle, or posterior hypothalamus but was not interfered with by control implants of cholesterol. Bilateral implants of either cholesterol or atropine into the anterior pituitary failed to alter the increase in plasma LH following castration but both types of implants interfered with the postcastration rise in FSH, possibly because of trauma to the pituitary from the cannulae. It is suggested that hypothalamic cholinergic synapses may play a role in stimulating the increased LHRH release which induces the postcastration rise in gonadotropins.
将硫酸阿托品双侧植入雄性大鼠大脑的不同部位或垂体前叶，然后测定植入物对去势后血浆促卵泡激素（FSH）和促黄体生成素（LH）升高的影响。在大脑皮层植入了植入物的动物中，去势后16小时时两种促性腺激素仍会增加。在下丘脑前部、中部或后部植入阿托品可阻断去势后FSH和LH的升高，但胆固醇对照植入物不会产生干扰。将胆固醇或阿托品双侧植入垂体前叶未能改变去势后血浆LH的升高，但两种植入物均干扰了去势后FSH的升高，这可能是由于插管对垂体造成了损伤。研究表明，下丘脑胆碱能突触可能在刺激促性腺激素释放激素（LHRH）释放增加中发挥作用，而这种增加会导致去势后促性腺激素升高。
