Brancato R, Carones F, Morico A, Venturi E, Vigo L, Spinelli A, Gobbi P G
Department of Ophthalmology and Visual Sciences, Scientific Institute San Raffaele Hospital, University of Milano, Italy.
Eur J Ophthalmol. 1997 Jul-Sep;7(3):203-10. doi: 10.1177/112067219700700301.
This paper presents the results of the first human trial on the correction of hyperopia using an erodible mask excimer laser delivery system coupled to an axicon.
We treated 17 eyes of 17 patients (age range 34-62 years) for the correction of +3.21 +/- 1.04 D (range +1.00 to +4.00 D). The hyperopic correction was made using an erodible mask inserted on the laser optical pathway, to produce a circular ablation measuring 6.5 mm in diameter. An axicon was then used to create a blend transition zone from 6.5 mm up to 9.4 mm in diameter. Eyes were evaluated at one, three and six months after surgery.
Reepithelization was always observed by the fifth postoperative day, despite the large area of deepithelization (diameter 9.5 mm). Mean refractive error one month after treatment was -2.44 +/- 1.59 D (range 0.00 to -6.50 D). Five eyes (29.4%) had a best corrected visual acuity loss more than two to three lines; all eyes showed mild annular haze not involving the central part of the cornea. Six months after treatment, mean refractive error was -0.88 +/- 0.99 D (range +0.50 to -3.00 D). Compared to preoperative status, 13 eyes (76.5%) showed an improvement in uncorrected distance visual acuity (1-8 lines), and 14 eyes (82.4%) showed an improvement in uncorrected vision at reading distance (3-7 lines). Two eyes (11.7%) showed a best corrected visual acuity loss of two of three lines.
These preliminary results indicate this approach is effective in reducing hyperopia, while its predictability has still to be proved in a larger treatment group with longer follow-up. A cautious approach to this technique is still advisable, especially for higher hyperopic corrections, in view of the large best corrected visual acuity loss seen in two eyes at six months.
本文介绍了首次使用与轴棱锥耦合的可蚀性面罩准分子激光传输系统矫正远视的人体试验结果。
我们治疗了17例患者的17只眼(年龄范围34 - 62岁),以矫正+3.21±1.04 D(范围+1.00至+4.00 D)的远视。使用插入激光光路的可蚀性面罩进行远视矫正,以产生直径为6.5 mm的圆形消融区。然后使用轴棱锥创建一个从直径6.5 mm到9.4 mm的混合过渡区。在术后1个月、3个月和6个月对眼睛进行评估。
尽管去上皮面积较大(直径9.5 mm),但在术后第5天总是观察到上皮再形成。治疗后1个月的平均屈光不正为-2.44±1.59 D(范围0.00至-6.50 D)。5只眼(29.4%)的最佳矫正视力下降超过2至3行;所有眼睛均显示轻度环形混浊,未累及角膜中央部分。治疗后6个月,平均屈光不正为-0.88±0.99 D(范围+0.50至-3.00 D)。与术前状态相比,13只眼(76.5%)的未矫正远视力有改善(提高1 - 8行),14只眼(82.4%)的未矫正近视力有改善(提高3 - 7行)。2只眼(11.7%)的最佳矫正视力下降2至3行。
这些初步结果表明,这种方法在降低远视方面是有效的,但其可预测性仍有待在更大的治疗组中进行更长时间的随访来证明。鉴于6个月时2只眼出现较大的最佳矫正视力下降,对该技术仍应谨慎采用,尤其是对于较高度数的远视矫正。