Wild C P, Pisani P
Molecular Epidemiology Unit, Research School of Medicine, University of Leeds, UK.
IARC Sci Publ. 1997(142):143-58.
Carcinogen-DNA and carcinogen-protein adducts provide an integrated measure of carcinogen exposure, uptake and absorption, metabolism, DNA repair and cell turnover. As such they promise to provide a more objective and relevant measure of exposure than that which can be derived from questionnaires and measures of ambient levels of carcinogen. Nevertheless, the interpretation of adduct measurements made in human tissues and body fluids requires an understanding of a number of factors. These include the sensitivity and specificity of the measurement, the temporal relationship between exposure and adduct level and the mechanistic role of the adduct in the process of carcinogenesis. The application of such biomarkers in epidemiological studies therefore necessitates careful consideration of optimal study design. The above issues are illustrated in this chapter with examples from studies in both animal models and human populations.
致癌物 - DNA加合物和致癌物 - 蛋白质加合物提供了一种对致癌物暴露、摄取与吸收、代谢、DNA修复及细胞更新的综合衡量指标。因此，它们有望提供一种比通过问卷调查和环境致癌物水平测量所获得的指标更为客观且相关的暴露衡量方法。然而，对在人体组织和体液中进行的加合物测量结果进行解读，需要了解多个因素。这些因素包括测量的灵敏度和特异性、暴露与加合物水平之间的时间关系以及加合物在致癌过程中的机制作用。因此，在流行病学研究中应用此类生物标志物需要仔细考虑优化研究设计。本章通过动物模型研究和人群研究的实例来说明上述问题。
