Temporal and spatial control of the adenovirus proteinase by both a peptide and the viral DNA.
作者信息
Mangel W F, Toledo D L, Ding J, Sweet R M, McGrath W J
机构信息
Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA.
出版信息
Trends Biochem Sci. 1997 Oct;22(10):393-8. doi: 10.1016/s0968-0004(97)01123-7.
PMID:9357315
Abstract
The adenovirus proteinase (AVP) uses both an 11-amino acid peptide (pVIc) and the viral DNA as cofactors to increase its catalytic rate constant 6000-fold. The crystal structure of an AVP-pVIc complex at 2.6-A resolution reveals a new protein fold of an enzyme that is the first member of a new class of cysteine proteinases, which arose via convergent evolution.
摘要
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