Cifuentes O L, Jorquera G H
Departamento de Biología Celular y Genética, Facultad de Medicina, Universidad de Chile, Santiago.
Hum Hered. 1997 Sep-Oct;47(5):288-94. doi: 10.1159/000154426.
The inclusion of DNA polymorphism into paternity analysis represents a major advance since it allows one to achieve a high probability of exclusion. This is of particular importance in paternity cases in which the mother and the alleged father are close relatives. The purpose of this article is to demonstrate an approach to calculate the probability of exclusion and to compute the paternity index in case of father-daughter incest using data from multiallelic loci that can be obtained with a single locus probe. The global probability of exclusion achieved at a multiallelic locus, in cases of father-daughter incest, is lower than the one obtained when both parents are not relatives. The probability of exclusion of each mother-offspring pair is different from that obtained when the parents are not close relatives. Among mother-offspring pairs having the same genotype, the probability of exclusion is zero, and in such a condition, the locus is not informative. To obtain a high exclusion capability, it is necessary to analyze several independent loci in which both the mother and the child have different genotypes. Expressions to obtain the paternity index for all the possible combinations of mother-offspring-alleged father in cases of father-daughter incest are derived and discussed.
将DNA多态性纳入亲子鉴定分析是一项重大进展，因为它能使排除亲子关系的概率很高。这在母亲和被指控父亲为近亲的亲子鉴定案件中尤为重要。本文的目的是展示一种方法，利用单基因座探针获得的多等位基因座数据，计算父女乱伦情况下的排除概率和亲子关系指数。在父女乱伦的情况下，多等位基因座实现的全局排除概率低于父母无亲缘关系时的排除概率。每对母子的排除概率与父母非近亲时的排除概率不同。在具有相同基因型的母子对中，排除概率为零，在这种情况下，该基因座无信息价值。为了获得高排除能力，有必要分析几个母亲和孩子基因型不同的独立基因座。推导并讨论了在父女乱伦情况下，针对所有可能的母子 - 被指控父亲组合获取亲子关系指数的表达式。
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