Sykes M, Zhao Y, Yang Y G
Bone Marrow Transplantation Section, Massachusetts General Hospital/Harvard Medical School, Boston 02129, USA.
World J Surg. 1997 Nov-Dec;21(9):932-8. doi: 10.1007/s002689900329.
The transplantation of donor hematopoietic tissue prior to organ xenografting has the potential to induce lasting T cell tolerance and, possibly, tolerance of natural antibody-producing B cells. However, the development of specific and nontoxic methods of overcoming the immunologic and physiologic barriers to xenogeneic marrow engraftment is a major challenge that must be met before this goal can be achieved. A greater understanding of the species specificity of molecular interactions important for hematopoiesis and cell homing is a first step toward transcending these physiologic barriers. Perhaps most promising is the potential associated with the use of nonprimate xenogeneic donors genetically engineered to make donor tissues more readily capable of surviving and, in the case of hematopoietic cells, competing with host tissues for survival in a human environment.
在进行器官异种移植之前移植供体造血组织，有可能诱导持久的T细胞耐受，并且可能诱导产生天然抗体的B细胞的耐受。然而，在实现这一目标之前，开发克服异种骨髓植入的免疫和生理障碍的特异性且无毒的方法是一项必须应对的重大挑战。更好地理解对造血和细胞归巢重要的分子相互作用的物种特异性，是跨越这些生理障碍的第一步。也许最有前景的是利用经过基因工程改造的非灵长类异种供体的潜力，以使供体组织更易于存活，并且就造血细胞而言，能够在人类环境中与宿主组织竞争生存。
