[Modulation of 5-fluorouracil with folinic acid in advanced colorectal cancers. Groupe d'étude et de recherche sur les cancers de l'ovaire et digestifs (GERCOD)].
作者信息
de Gramont A, Louvet C, André T, Tournigand C, Raymond E, Molitor J L, Krulik M
机构信息
Service de médecine interne-oncologie, hôpital Saint-Antoine, Paris, France.
出版信息
Rev Med Interne. 1997;18 Suppl 4:372s-378s. doi: 10.1016/s0248-8663(97)83768-x.
PMID:9365715
Abstract
The rational of leucovorin modulation of 5-fluorouracil and the clinical results in colorectal cancer are reviewed with special emphasis on the monthly schedule of low dose leucovorin and 5FU bolus for 5 consecutive days (NCCTG-Mayo Clinic regimen) and the bimonthly schedule of high-dose leucovorin and 5FU bolus plus continuous infusion for two consecutive days (LV5FU2) which is now considered as a new standard.
摘要
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