Weston W L, Morelli J G, Rogers M
Royal Alexandria Hospital for Children, Sydney, Australia.
J Am Acad Dermatol. 1997 Nov;37(5 Pt 2):848-50. doi: 10.1016/s0190-9622(97)80009-6.
Erythema multiforme and Stevens-Johnson syndrome are both characterized by areas of epithelial necrosis. An important clinical feature that distinguishes the two is the extensive mucosal necrosis in Stevens-Johnson syndrome but not in erythema multiforme. Because significant and serious complications may develop with Stevens-Johnson syndrome and not with erythema multiforme, it is important to differentiate between the conditions. We describe three boys with herpes simplex virus-associated erythema multiforme who had severe necrosis of the lips develop and were initially diagnosed with Stevens-Johnson syndrome. The lip lesions were large target lesions of erythema multiforme rather than the extensive necrosis seen in Stevens-Johnson syndrome and all three had a benign course.
多形红斑和史蒂文斯-约翰逊综合征均以上皮坏死区域为特征。区分两者的一个重要临床特征是史蒂文斯-约翰逊综合征存在广泛的黏膜坏死,而多形红斑则无。由于史蒂文斯-约翰逊综合征可能会引发严重并发症,而多形红斑不会,因此区分这两种病症很重要。我们描述了三名患有单纯疱疹病毒相关性多形红斑的男孩,他们出现了严重的唇部坏死,最初被诊断为史蒂文斯-约翰逊综合征。唇部病变是多形红斑的大型靶形损害,而非史蒂文斯-约翰逊综合征中所见的广泛坏死,且三名患者病程均为良性。