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大鼠伏隔核亚区域中的神经元:静脉注射可卡因自我给药后数秒内的相位性放电时间锁定。

Neurons in accumbens subterritories of the rat: phasic firing time-locked within seconds of intravenous cocaine self-infusion.

作者信息

Uzwiak A J, Guyette F X, West M O, Peoples L L

机构信息

Department of Psychology, Rutgers, The State University of New Jersey, New Brunswick 08903, USA.

出版信息

Brain Res. 1997 Sep 5;767(2):363-9. doi: 10.1016/s0006-8993(97)00752-x.

DOI:10.1016/s0006-8993(97)00752-x
PMID:9367270
Abstract

Individual neurons were recorded extracellularly in the nucleus accumbens (NAcc) of rats during cocaine self-administration sessions. NAcc neurons exhibited a variety of phasic changes in firing rate within the few seconds before and/or after cocaine self-infusion. Analysis of the topographical distribution of the phasic firing patterns showed that there were no differences between NAcc subterritories in the nature of phasic changes in firing exhibited by neurons in relation to cocaine self-infusion. However, the prevalence of phasic firing was lower in the border regions of the caudal shell and within the caudal shell itself relative to the remainder of the NAcc.

摘要

在大鼠可卡因自我给药期间,对伏隔核(NAcc)中的单个神经元进行细胞外记录。伏隔核神经元在可卡因自我注射前和/或后的几秒钟内,放电频率呈现出多种阶段性变化。对阶段性放电模式的地形分布分析表明,伏隔核不同亚区的神经元在与可卡因自我注射相关的放电阶段性变化性质上没有差异。然而,相对于伏隔核的其余部分,尾壳边界区域和尾壳内部的阶段性放电发生率较低。

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