Borkhardt H L, Zielinski S
Institute for Medical Microbiology, Otto von Guericke University of Magdeburg, Germany.
J Med Microbiol. 1997 Nov;46(11):965-72. doi: 10.1099/00222615-46-11-965.
The aim of the present study was to investigate the biological role of cardiolipin antibodies during Treponema pallidum infection. Inhibition of the binding of treponemal specific antibodies at the early and late stages of infection by cardiolipin antibodies was shown in the fluorescence treponemal antibody absorption (FTA-ABS) test and T. pallidum immobilisation (TPI) test. Incubation of treponemes with cardiolipin antibodies followed by a second incubation with treponemal specific antibodies resulted in a reduction of the titres of the FTA-ABS test and the TPI test. The findings suggest that cardiolipin antibody production should be considered as a virulence mechanism of pathogenic treponemes with the purpose of evading the host defence mechanisms.
本研究的目的是调查心磷脂抗体在梅毒螺旋体感染过程中的生物学作用。在心磷脂抗体吸收荧光密螺旋体抗体试验（FTA-ABS试验）和梅毒螺旋体制动试验（TPI试验）中，显示心磷脂抗体在感染的早期和晚期抑制密螺旋体特异性抗体的结合。将密螺旋体与心磷脂抗体孵育，然后再与密螺旋体特异性抗体孵育，导致FTA-ABS试验和TPI试验的滴度降低。这些发现表明，心磷脂抗体的产生应被视为致病性密螺旋体逃避宿主防御机制的一种毒力机制。
