Bérard M, Tripier M F, Gambarelli D, Choux R, Grisoli F, Toga M
Acta Neuropathol. 1976 Jun 15;35(2):139-50. doi: 10.1007/BF00690560.
One case of malignant tumour of the left nasal cavity is reported in a woman 56 year old, affected by the disease 24 years. Numerous recurrences appeared and various histological diagnoses were performed. At the last surgery, the tumour invaded the ethmoid and was a typical olfactory esthesioneurocytoma. By electron microscopy, mature ganglion cells with dense cored vesicles (neurosecretory granules) were densely packed. Neuritic processes with microtubules were rarely normal in size and their content was most often abnormal; furthermore dystrophic axons were noted in great number.
报告了一例56岁女性左侧鼻腔恶性肿瘤病例,该患者患病24年。出现了多次复发,并进行了各种组织学诊断。在最后一次手术时,肿瘤侵犯了筛骨,是典型的嗅神经母细胞瘤。通过电子显微镜观察,成熟的神经节细胞含有密集的有芯小泡(神经分泌颗粒),紧密排列。含有微管的神经突起大小很少正常,其内容物大多异常;此外,还发现大量营养不良性轴突。