在猫黑质-纹状体多巴胺能神经元激活期间，乙酰胆碱对多巴胺释放的突触前刺激作用受到抑制。

The presynaptic stimulating effect of acetylcholine on dopamine release is suppressed during activation of nigro-striatal dopaminergic neurons in the cat.

作者信息

Giorguieff-Chesselet M F, Kemel M L, Glowinski J

出版信息

Neurosci Lett. 1979 Oct;14(2-3):177-82. doi: 10.1016/0304-3940(79)96144-5.

Abstract

Acetylcholine (ACh) (10(-5) M) in the presence of eserine (2 . 10(-4) M) stimulated the release of [3H]dopamine (DA) continuously formed from [3H]tyrosine, when delivered to a push-pull cannula implanted in the left caudate nucleus of halothane anaesthetized cats. This effect was transient and followed by a second increase in [3H]DA release after removal of ACh and eserine. These changes in [3H]DA release during and after ACh application were no longer seen during activation of the dopaminergic neurons by continuous delivery of substance P to the ipsilateral substantia nigra (SN). These results indicate that the presynaptic regulation of DA release by ACh is dependent on the rate of firing of nigro-striatal dopaminergic neurons.

摘要

在氟烷麻醉的猫的左尾状核植入推挽式套管后，当给予10⁻⁵M的乙酰胆碱（ACh）并同时存在2×10⁻⁴M的毒扁豆碱时，可刺激由[³H]酪氨酸持续生成的[³H]多巴胺（DA）的释放。这种作用是短暂的，在去除ACh和毒扁豆碱后，[³H]DA释放会再次增加。在通过持续向同侧黑质（SN）递送P物质激活多巴胺能神经元的过程中，ACh应用期间和之后[³H]DA释放的这些变化不再出现。这些结果表明，ACh对DA释放的突触前调节取决于黑质-纹状体多巴胺能神经元的放电频率。