Acid-sensing by carotid body is inhibited by blockers of voltage-sensitive Ca2+ channels.
作者信息
Roy A, Rozanov C, Iturriaga R, Mokashi A, Lahiri S
机构信息
University of Pennsylvania, School of Medicine, Department of Physiology, Philadelphia 19104-6085, USA.
出版信息
Brain Res. 1997 Sep 26;769(2):396-9. doi: 10.1016/s0006-8993(97)00820-2.
PMID:9374213
Abstract
The membrane potential hypothesis that the responses to hypercapnia of carotid chemosensory activity is mediated by voltage-gated Ca2+ channels was investigated by measuring directly the chemosensory output from rat and cat carotid bodies, perfused and superfused in vitro. We found that the inorganic and organic blockers of voltage-gated Ca2+ channels suppressed the hypercapnic responses, thereby supporting the membrane potential hypothesis.
摘要
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