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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gladis-Villanueva M M, Usera F, Toro M J

DPTO, de Fisiologia y Farmacologia, Facultad de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.

Gen Pharmacol. 1997 Sep;29(3):409-14. doi: 10.1016/s0306-3623(96)00467-3.

The present study investigates whether chemical sympathectomy compromises the relaxation of the rabbit femoral artery precontracted with serotonin. The vasodilating agents promoted cyclic adenosine monophosphate (cAMP) accumulation or opening of the potassium channels. The effect of denervation on the adenylyl cyclase transduction pathway was also studied. 2. 6-Hydroxydopamine treatment did not impair the relaxation to adenosine, 8-bromoadenosine-cAMP (a membrane-permeable analog of cAMP) and 3-isobutyl-1-methylxanthine (a cAMP phosphodiesterase inhibitor). Moreover, denervation enhanced the relaxation to forskolin (a direct Gs-type protein activator) and pinacidil (a potassium channel opener). 3. Denervation modified neither adenosine diphosphate ribosylation of Gs- and Gi-proteins nor adenylyl cyclase activity.

本研究调查化学性交感神经切除术是否会损害用血清素预收缩的兔股动脉的舒张功能。血管舒张剂促进环磷酸腺苷（cAMP）积累或钾通道开放。还研究了去神经支配对腺苷酸环化酶转导途径的影响。2. 6-羟基多巴胺处理并未损害对腺苷、8-溴腺苷-cAMP（cAMP的膜通透性类似物）和3-异丁基-1-甲基黄嘌呤（一种cAMP磷酸二酯酶抑制剂）的舒张反应。此外，去神经支配增强了对福斯可林（一种直接的Gs型蛋白激活剂）和匹那地尔（一种钾通道开放剂）的舒张反应。3. 去神经支配既未改变Gs-和Gi-蛋白的二磷酸腺苷核糖基化，也未改变腺苷酸环化酶活性。

Gladis-Villanueva M M, Usera F, Toro M J

DPTO, de Fisiologia y Farmacologia, Facultad de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.

Gen Pharmacol. 1997 Sep;29(3):409-14. doi: 10.1016/s0306-3623(96)00467-3.

The present study investigates whether chemical sympathectomy compromises the relaxation of the rabbit femoral artery precontracted with serotonin. The vasodilating agents promoted cyclic adenosine monophosphate (cAMP) accumulation or opening of the potassium channels. The effect of denervation on the adenylyl cyclase transduction pathway was also studied. 2. 6-Hydroxydopamine treatment did not impair the relaxation to adenosine, 8-bromoadenosine-cAMP (a membrane-permeable analog of cAMP) and 3-isobutyl-1-methylxanthine (a cAMP phosphodiesterase inhibitor). Moreover, denervation enhanced the relaxation to forskolin (a direct Gs-type protein activator) and pinacidil (a potassium channel opener). 3. Denervation modified neither adenosine diphosphate ribosylation of Gs- and Gi-proteins nor adenylyl cyclase activity.

本研究调查化学性交感神经切除术是否会损害用血清素预收缩的兔股动脉的舒张功能。血管舒张剂促进环磷酸腺苷（cAMP）积累或钾通道开放。还研究了去神经支配对腺苷酸环化酶转导途径的影响。2. 6-羟基多巴胺处理并未损害对腺苷、8-溴腺苷-cAMP（cAMP的膜通透性类似物）和3-异丁基-1-甲基黄嘌呤（一种cAMP磷酸二酯酶抑制剂）的舒张反应。此外，去神经支配增强了对福斯可林（一种直接的Gs型蛋白激活剂）和匹那地尔（一种钾通道开放剂）的舒张反应。3. 去神经支配既未改变Gs-和Gi-蛋白的二磷酸腺苷核糖基化，也未改变腺苷酸环化酶活性。